Table 4 of Luna, Mol Vis 2009; 15:534-544. Table 4 of Luna, Mol Vis 2009; 15:534-544.
Table 4. Extracellular matrix changes in gene expression after CMS in HTM cells.
Gene |
Fold |
p value |
GenBank accession number |
|---|---|---|---|
| ECM genes upregulated after CMS | |||
| ECM regulators/modifiers | |||
| Matrix metalloproteinase 3 (stromelysin 1, progelatinase) | 29.78 | 1.13E-05 | NM_002422 |
| Matrix metalloproteinase 10 (stromelysin 2) | 26.72 | 0.000597 | NM_002425 |
| Bone morphogenetic protein 2 | 20.07 | 0.000553 | NM_001200 |
| Fibroblast growth factor 1 (acidic) | 13.75 | 0.00479 | NM_000800 |
| Carbohydrate (chondroitin 4) sulfotransferase 11 | 6.801 | 0.00106 | NM_018413 |
| Vascular endothelial growth factor C | 5.917 | 7.05E-05 | NM_005429 |
| Hyaluronan synthase 2 | 5.388 | 0.00474 | NM_005328 |
| Heparan sulfate (glucosamine) 3-O-sulfotransferase 1 | 5.377 | 0.00618 | NM_005114 |
| Bone morphogenetic protein 6 | 5.079 | 0.00223 | NM_001718 |
| Carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 | 4.423 | 0.000172 | NM_004267 |
| Heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | 4.329 | 1.13E05 | NM_006042 |
| Tumor necrosis factor, alpha-induced protein 6 | 4.082 | 0.00033 | NM_007115 |
| Plasminogen activator, tissue | 3.236 | 0.00284 | NM_000931 |
| Tissue factor pathway inhibitor 2 | 2.74 | 0.00486 | NM_006528 |
| Procollagen C-endopeptidase enhancer 2 | 2.594 | 0.00373 | NM_013363 |
| A disintegrin-like and metalloprotease with thrombospondin type 1 motif, 1 | 2.081 | 0.0285 | NM_006988 |
| Proteoglycans | |||
| Endothelial cell-specific molecule 1 | 33.41 | 0.000613 | NM_007036 |
| Syndecan 1 | 2.802 | 0.00156 | NM_002997 |
| Chondroitin sulfate proteoglycan 4 (melanoma-associated) | 4.376 | 0.000852 | NM_001897 |
| ECM genes downregulated after CMS | |||
| ECM regulators/modifiers | |||
| Transforming growth factor, beta receptor III (betaglycan, 300 kDa) | -2.864 | 0.00214 | NM_003243 |
| Thrombospondin 1 | -2.883 | 0.0163 | NM_003246 |
| A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) | -2.771 | 0.0196 | NM_007038 |
| Transforming growth factor, beta 3 | -2.64 | 0.00823 | NM_003239 |
| Bone morphogenetic protein receptor, type IA | -2.494 | 0.0243 | NM_004329 |
| Sulfatase 2 | -2.336 | 0.00141 | AB033073 |
| Sulfatase 1 | -2.283 | 0.0124 | AB029000 |
| Lysyl oxidase-like 4 | -2.144 | 0.000569 | NM_032211 |
| Proteoglycans | |||
| Glypican 4 | -3.08 | 0.00368 | NM_001448 |
| Osteoglycin (osteoinductive factor, mimecan) | -2.297 | 0.0105 | NM_033014 |
| Matrix proteins | |||
| Collagen, type VIII, alpha 1 | -2.594 | 0.0103 | NM_001850 |
| Laminin, beta 1 | -2.443 | 0.0023 | NM_002291 |
| Collagen, type IV, alpha 3 (Goodpasture antigen) binding protein | -2.124 | 0.00719 | NM_005713 |