Figure 4. Amino acid
sequence alignment of CRYGS. Multiple
alignment of partial amino acid sequences of CRYGS from different Homo sapiens γ crystallins (γ S, γ A, γ
B, γ C, γ D) and from different species indicate that valine at
position 42
(red) is highly conserved. The valine to methionine substitution at
codon 42
(p.V42M) in γ S in the proband’s (III:2) sequence is also highlighted
(pink).