Figure 1. Retinal ganglion cell (RGC) degeneration in DBA/2J mice. A: RGC labeled by neurotracer in flat-mounted retina of DBA/2J mice at 1 month of age. B,C: Substantial loss of RGC in flat-mounted retina from DBA/2J mice at 6 and 15 months of age, respectively. D: Normal RGC density in whole mount retina from C57BL/6J mice. Red arrows indicate 4-di-10-ASP labeled RGC. E: RGC density in paraffin cross-section from DBA/2J mice at 1 month of age. F,G: Substantial loss of RGC in retina from DBA/2J mice at 6 and 15 months old, respectively. H: Normal RGC density in paraffin cross-section from C57BL/6J mice. Black arrows indicate RGC. Insets show higher magnification.