Figure 5. Distribution of Atm mRNA in the adult mouse cerebellum. No specific signal was detected with the sense probe (A). Labeled Atm mRNA was detected in adult mouse cerebellum tissue sections by in situ hybridization using specific digoxigenin-labeled antisense riboprobe (B). A high magnification of Atm hybridization signals in the granular cell (GL), molecular cell (ML), and Purkinje cell (PL) layers is shown (C-D).