Figure 3. Distribution of Atm mRNA in adult mouse retina. Atm mRNA was reproducibly detected in adult mouse retinas by in situ hybridization using specific antisense digoxigenin (DIG)-labeled riboprobe. No specific hybridization signal was detected with the sense probe (A). B: Labeled Atm mRNA appeared as dark blue or purple precipitates in all nuclear layers of the retina. C: A high magnification of the outer portion of the neuroretina is shown. Abbrevations: choroid cells (Ch), ganglion cell layer (GCL), inner nuclear layer (INL); outer nuclear layer (ONL); photoreceptor inner segment (PIS), photoreceptor outer segment (POS), retinal pigment epithelium (RPE), and scleral cells (Sc).