Table 1 of Chikama, Mol Vis 2009; 15:2896-2904. Table 1 of Chikama, Mol Vis 2009; 15:2896-2904.
Table 1. Clinical characteristics of patients with S-1–induced ocular mucositis.
Patient |
Sex |
Age (years) |
Primary disease |
S-1 dose (mg/day)/ treatment duration (months)/ onset of ocular symptoms (months) | Ocular symptoms |
General symptoms |
Visual acuity at first visit |
Withdrawal of S-1 administration |
Progress |
|---|---|---|---|---|---|---|---|---|---|
| 1 | F | 52 | Gastric cancer | 110/24/12 | Bil. visual disturbance Bil. foreign body sensation | Skin pigmentation | OD = 0.05 (0.7) OS = 0.07 (1.0) | Yes | Improved OD = 0.1 (1.2) OS = 0.08 (1.5) |
| 2 | M | 73 | Gastric cancer | Unclear/24/2 | Bil. visual disturbance | Skin pigmentation | OD = 0.2 (0.2) OS = 0.09 (0.15) | Yes | Residual epithelial disorder OD = 0.4 (0.7) OS = 0.09 (0.4) |
| 3 | M | 68 | Rectal cancer | 100/21/2 | Visual disturbance OD Bil. tearing | None | OD = 0.04 (0.05) OS = 0.6 (0.7) | Yes | Improved but duct obstruction irreversible OD = 1.0 (NC) OS = 0.7 (0.9) |
| 4 | F | 58 | Breast cancer | 120/15/1.5 | Bil. foreign body sensation | Skin dryness Nail abnormality | OD = 0.7 (1.0) OS = 0.8 (1.2) | Yes | Residual epithelial disorder OD = 0.6 (0.7) OS = 0.2 (0.5) |
| 5 | M | 57 | Gastric cancer | 125/68/36 | Bil. foreign body sensation Bil. tearing | Skin pigmentation | OD = 0.9 (1.2) OS = 0.9 (NC) | Yes | Improved but duct obstruction irreversible OD = 0.8 (0.9) OS = 1.0 (NC) |
| 6 | M | 66 | Gastric cancer | 120/>72/4 | Bil. foreign body sensation Bil. tearing | Skin pigmentation | OD = 0.8 (NC) OS = 0.8 (NC) | No | Improved slightly but duct obstruction irreversible OD = 0.7 (1.2) OS = 1.2 (NC) |
| 7 | F | 72 | Gastric cancer | 80/9/3 | Bil. visual disturbance Bil. tearing | None | OD = 0.8 (0.9) OS = 0.4 (0.4) | Yes | Improved OD = 0.8 (1.0) OS = 0.9 (NC) |
| 8 | M | 60 | Biliary tract cancer | 100/8/6 | Bil. visual disturbance Bil. tearing | Skin pigmentation Skin dryness | OD = 0.3 (0.5) OS = 0.2 (0.3) | Yes | Improved but duct obstruction irreversible OD = 0.8 (1.2) OS = 0.5 (1.2) |
| 9 | F | 59 | Gastric cancer | 50/6/6 | Bil. foreign body sensation Bil. tearing | None | OD = 0.05 (1.0) OS = 0.06 (1.0) | Yes | Improved OD = 0.05 (1.0) OS = 0.06 (1.0) |
| 10 | F | 67 | Colon cancer | 100/12/12 | Bil. foreign body sensation Bil. tearing | Nail abnormality | OD = 0.3 (0.4) OS = 0.4 (0.6) | Yes | Improved OD = 0.9 (NC) OS = 1.0 (NC) |
| 11 | M | 62 | Gastric cancer | 125/3/2 | Bil. foreign body sensation Bil. tearing | Skin dryness Skin pigmentation Nail abnormality | OD = 0.7 (0.7) OS = 0.15 (0.2) | Yes | Improved OD = 0.5 (0.8) OS = 0.3 (0.5) |
| 12 | M | 78 | Lung cancer | 100/3/2 | Bil. visual disturbance Bil. foreign body sensation | Skin pigmentation Nail abnormality | OD = 0.3 (0.7) OS = 0.4 (NC) | Yes | Improved OD = 0.5 (0.7) OS = 0.9 (NC) |