Molecular Vision: Štabuc-Šilih, Mol Vis 2009; 15:2848-2860. Table 6

Table 6. Genotype representation and associations under additive model between keratoconus patients and controls.

COL4A3 polymorphism	Genotype	Genotype comparison	Additive model
COL4A3 polymorphism	Genotype	Genotype comparison	p-value	OR	RR
G43R	127GG	GG versus CC	NC	NC	NC
	127CC	GC versus GG	1.0000
	127GC	GC versus CC	NC	NC	NC
P141L	422CC	CC versus TT	0.0325	7.138	4.849
	422TT	CT versus CC	0.0262	1.971	1.447
	422CT	CT versus TT	0.0022	14.069	7.016
E162G	485AA	AA versus GG	0.2550
	485GG	AG versus AA	0.4790
	485AG	AG versus GG	0.2289
D326Y	976GG	GG versus TT	<0.0001	52.364	21.926
	976TT	GT versus GG	<0.0001	0.0875	0.1905
	976GT	GT versus TT	0.2520
H451R	1352AA	AA versus GG	NC	NC	NC
	1352GG	AG versus AA	1.0000
	1352AG	AG versus GG	NC	NC	NC
G484G	1452GG	GG versus AA	NC	NC	NC
	1452AA	GA versus GG	0.8306
	1452GA	GA versus AA	NC	NC	NC
P574L	1721CC	CC versus TT	0.3248
	1721TT	CT versus CC	0.8825
	1721CT	CT versus TT	0.1686
G895G	2685AA	AA versus CC	0.0352	0.3158	0.5667
	2685CC	AC versus AA	0.6933
	2685AC	AC versus CC	0.0667
COL4A4 polymorphism	Genotype	Genotype comparison	Additive model
COL4A4 polymorphism	Genotype	Genotype comparison	p-value	OR	RR
P482S	1444CC	CC versus TT	0.1857
	1444TT	CT versus CC	0.0726
	1444CT	CT versus TT	0.0061	0.3056	0.5370
G545A	1634GG	GG versus CC	NC	NC	NC
	1634CC	GC versus GG	0.8130
	1634GC	GC versus CC	NC	NC	NC
G789G	2367AA	AA versus TT	0.4033
	2367TT	AT versus AA	0.6270
	2367AT	AT versus TT	0.3684
M1327V	3979AA	AA versus GG	<0.0001	0.0853	0.1535
	3979GG	AG versus AA	<0.0001	13.683	7.030
	3979AG	AG versus GG	0.6567
V1516V	4548AA	AA versus GG	0.2864
	4548GG	AG versus AA	0.1940
	4548AG	AG versus GG	0.0153	2.373	1.716
F1644F	4932CC	CC versus TT	0.0021	3.399	2.240
	4932TT	CT versus CC	0.3283
	4932CT	CT versus TT	0.0148	2.561	1.916

Significant differences are shown in bold. Statistics were based on genotype representation shown in Table 5 (104 keratoconus patients and 157 controls). NC- not calculated, Genotype: Genotypes found representing each polymorphism in cases and controls. Fisher’s exact test was used for statistics. Genotype comparison: genotypes compared against each other. Differences between genotypes are significant when two-sided p-value (p-value) is less than 0.05. OR: Odds ratio, RR: relative risk. OR and RR are shown only for genotypes with significant differences (p-value less than 0.05).