Table 4 of Štabuc-Šilih, Mol Vis 2009; 15:2848-2860.

Table 4. Allele frequencies and their significances in COL4A3 and COL4A4 polymorphisms between keratoconus patients and control population.

COL4A3
polymorphism
Allele		 Cases
(n=208)		 Controls
(n=314)
p-value
OR
RR
G43R 127G 199 301      
  127C 9 13 1.0000    
P141L 422C 172 261      
  422T 36 53 0.9059    
E162G 485A 174 262      
  485G 34 52 1.0000    
D326Y 976G 199 187      
  976T 9 127 <0.0001 15.017 7.790
H451R 1352A 193 292      
  1352G 15 22 1.0000    
G484G 1452G 199 298      
  1452A 9 16 0.8349     
P574L 1721C 118 166      
  1721T 90 148 0.4195    
G895G 2685A 137 227      
  2685C 71 87 0.1208    
COL4A4
polymorphism
Allele		 Cases
(n=208)		 Controls
(n=314)
p-value
OR
RR
P482S 1444C 117 182      
  1444T 91 132 0.7183    
G545A 1634G 201 301      
  1634C 7 13 0.8168    
G789G 2367G 200 302      
  2367A 8 12 1.0000    
M1327V 3979A 74 182      
  3979G 134 132 <0.0001 0.4005 0.5738
V1516V 4548A 119 184      
  4548G 89 130 0.7861    
F1644F 4932C 136 163      
  4932T 72 151 0.0028 1.750 1.409

Cases: number of alleles found in keratoconus patients, Controls: number of alleles found in healthy blood donor population, n: number of all alleles, p-value: two sided p-value calculated with Fisher’s exact test for determining the significance between differences in alleles found in keratoconus patients and controls for each polymorphism, OR: odds ratio, RR: relative risk. OR and RR are shown only for polymorphisms for which allele differences are significant (p-value less than 0.05).

Štabuc-Šilih, Mol Vis 2009; 15:2848-2860. http://www.molvis.org/molvis/v15/a301

©2009 Molecular Vision http://www.molvis.org/molvis/

ISSN 1090-0535