Table 3 of Štabuc-Šilih, Mol Vis 2009; 15:2848-2860.

Table 3. Data about observed polymorphisms in keratoconus patients and controls with calculated deviation from Hardy-Weinberg equilibrium.


Polymorphism
Exon		 dbSNP
ref ID		 Hardy-Weinberg CHI (p-value)
Cases Controls
COL4A3
G43R 2 rs13424243 0.2127 (p>0.2) 0.2928 (p>0.2)
P141L 7 rs10178458 2.1005 (p<0.2) 18.333 (p<0.0001)
E162G 9 rs6436669 1.6271 (p>0.2) 0.9575 (p>0.2)
D326Y 17 rs55703767 3.6385 (p<0.1) 11.6848 (p<0.001)
H451R 22 rs11677877 0.6282 (p>0.2) 0.8912 (p>0.2)
G484G 23 rs34019152 0.2127 (p>0.2) 0.4525 (p>0.2)
P574L 25 rs28381984 4.7767 (p<0.05) 0.8502 (p>0.2)
G895G 33 ref* 0.2376 (p>0.2) 5.8157 (p<0.02)
COL4A4
P482S 21 rs2229814 0.5769 (p>0.2) 30.0822 (p<0.0001)
G545A 23 rs1800516 0.1261 (p>0.2) 0.2928 (p>0.2)
G789G 28 rs56247709 5.0335 (p<0.025) 0.2478 (p>0.2)
M1327V 42 rs2229813 12.1981 (p<0.001) 9.1888 (p<0.01)
V1516V 47 rs2228555 0.6683 (p>0.2) 8.5342 (p<0.01)
F1644F 48 rs2228557 0.4009 (p>0.2) 1.3937 (p>0.2)

dbSNP ref ID: identity numbers for observed variants; ref*: polymorphism is not listed in dbSNP, but was reported by Wang et al. [34]. Hardy-Weinberg CHI (p-value): calculated chi values according to our data for cases and controls separately, and deviation between observed and expected numbers. When p-value equals or is less than 0.05 (5%) limit, then there is no statistical deviation from the Hardy-Weinberg equilibrium.

Štabuc-Šilih, Mol Vis 2009; 15:2848-2860. http://www.molvis.org/molvis/v15/a301

©2009 Molecular Vision http://www.molvis.org/molvis/

ISSN 1090-0535