Figure 5. NMDAR1 Interactome. A: The molecular network of direct physical, transcriptional, and enzymatic interactions with NMDAR1 (GRIN1), referred to as the NMDAR1 “interactome,” was derived from the HiMAP database. Using evidence from literature-confirmed interactions within the Human Protein Reference Database and predicted interactions generated by Bayesian Analysis, greater than >40,000 molecular relationships were queried. B: Subsets of the NMDA Interactome were created based on ligand specificity. In these subsets, the 25 genes in the NMDA interactome (above) were organized into progressively smaller subsets and further analyzed by GSEA.