Figure 2 of Gong, Mol Vis 2009; 15:2829-2840.


Figure 2. Chemical chaperones reduced the cellular aggregation of G98R αA-crystallin. A-C: Distribution of G98R αA-crystallin (CRYAA) in transfected B3 cells. Untreated B3 cells showed aggregated G98R CRYAA (A), which was reduced after 4-PBA (1 mM; B) and TMAO (100 mM; C) treatments. D: Semiquantitative scoring of intracellular CRYAA aggregates in cells. E: Staining index representing phenotype severity showed dramatic reduction after 4-PBA or TMAO treatment. 4-PBA: 4-phenylbutyric acid; TMAO: trimethylamine N-oxide