Table 4 of Schippert, Mol Vis 2009; 15:2720-2739. Table 4 of Schippert, Mol Vis 2009; 15:2720-2739.
Table 4. Pathways identified in the wild-type and the homozygous Egr-1 knockout mice by Ingenuity Pathway Analysis Software (wt/30 versus wt/42 and hm/30 versus hm/42).
| Pathways detected in wild-type mice (30 days versus 42 days, 54 differentially expressed genes): | |
|---|---|
| Pathway | Molecules |
| Arachidonic Acid Metabolism | Gpx3, Cyp2d6, Ptgds |
| Acute Phase Response Signaling | Ttr, Tf, A2m |
| FXR/RXR Activation | Pon1, Cyp27a1 |
| Pathways detected in Egr-1 knockout-mice (30 days versus 42 days, 215 differentially expressed genes): | |
| Pathway | Molecules |
| Synaptic Long-term Depression | Plcb4, Itpr2, Igf1r, Gna13, Prkca, Prkcb1 |
| Synaptic Long-term Potentiation | Plcb4, Itpr2, Atf2, Prkca, Prkcb1 |
| Huntington's Disease Signaling | Gnb1, Plcb4, Igf1r, Zdhhc17, Atf2, Prkca, Prkcb1 |
| PDGF Signaling | Crkl, Abl1, Prkca, Prkcb1 |
| Chemokine Signaling | Plcb4, Ppp1r12b, Prkca, Prkcb1 |
| VDR/RXR Activation | Igfbp3, Ncoa1, Prkca, Prkcb1 |
| FGF Signaling | Crkl, Fgf11, Atf2, Prkca |
| Ephrin Receptor Signaling | Gnb1, Crkl, Abl1, Gna13, Atf2, Rapgef1 |
| Axonal Guidance Signaling | Gnb1, Plcb4, Pfn1, Crkl, Abl1, Gna13, Prkca, Prkcb1 |
| Lysine Degradation | Setdb1, Nsd1, Ogdh |
| Actin Cytoskeleton Signaling | Pfn1, Diaph3, Crkl, Ppp1r12b, Fgf11, Gna13 |
| Circadian Rhythm Signaling | Arntl, Atf2 |
| G-Protein Coupled Receptor Signaling | Pde8a, Plcb4, Atf2, Prkca, Prkcb1 |
| Integrin Signaling | Tspan5, Crkl, Ppp1r12b, Abl1, Rapgef1 |
| Neuregulin Signaling | Crkl, Prkca, Prkcb1 |
| SAPK/JNK Signaling | Gnb1, Crkl, Gna13, Atf2 |
| ERK/MAPK Signaling | Crkl, Atf2, Rapgef1, Prkca, Prkcb1 |