Molecular Vision: Fang, Mol Vis 2009; 15:2710-2719. Table 3

Table 3. Allele distribution for tagging single nucleotide polymorphisms in VEGFR-2

SNP	Location in gene	Genomic location	Variation	Variant allele in controls, n (%)	Variant allele in cases, n (%)	Odds ratio (95% CI)	Unadjusted p-value	Adjusted p-value
rs7691507	3′ UTR	55637758	T to C	95 (18.8)	191 (18.5)	0.98 (0.75–1.29)	0.913	1.000
rs12642307	Intron 27	55646938	T to C	142 (28.1)	319 (31.0)	1.15 (0.91–1.45)	0.243	1.000
rs2125489	Intron 27	55648240	C to T	58 (11.5)	106 (10.3)	0.89 (0.63–1.24)	0.485	1.000
rs1531289	Intron 25	55649989	G to A	61 (28.9)	306 (29.7)	1.04 (0.82–1.32)	0.730	1.000
rs17709898	Intron 22	55652480	A to G	146 (39.1)	348 (33.8)	0.79 (0.64–0.99)	0.040	0.795
rs12505758	Intron 15	55661655	T to C	55 (10.9)	118 (11.5)	1.06 (0.76–1.49)	0.732	1.000
rs13109660	Intron 13	55665437	G to A	159 (31.4)	378 (36.7)	1.27 (1.01–1.59)	0.042	0.831
rs1870377	Exon 11	55667731	T to A	134 (26.5)	232 (22.5)	0.81 (0.63–1.03)	0.087	1.000
rs7654599	Intron 9	55670925	T to C	210 (41.5)	418 (40.6)	0.96 (0.78–1.20)	0.731	1.000
rs17085326	Intron 7	55672133	C to T	38 (7.5)	81 (7.9)	1.05 (0.70–1.57)	0.807	1.000
rs2034965	Intron 7	55672557	G to A	133 (26.3)	269 (26.1)	0.99 (0.78–1.26)	0.944	1.000
rs10020464	Intron 7	55673827	C to T	150 (29.6)	300 (29.1)	0.98 (0.77–1.23)	0.834	1.000
rs2305948	Exon 7	55674315	C to T	61 (12.1)	89 (8.6)	0.69 (0.49–0.97)	0.034	1.000
rs7692791	Intron 6	55674996	T to C	233 (46.1)	486 (47.2)	1.05 (0.85–1.30)	0.675	1.000
rs2305949	Exon 6	55675213	C to T	111 (21.9)	207 (20.1)	0.90 (0.69–1.16)	0.403	1.000
rs6837735	Intron 2	55680572	C to T	80 (15.8)	191 (18.5)	1.21 (0.91–1.61)	0.187	1.000
rs1531290	Intron 2	55681319	A to G	239 (47.2)	509 (49.4)	1.09 (0.88–1.35)	0.421	1.000
rs12502008	Intron 1	55685799	G to T	180 (35.6)	368 (35.7)	1.01 (0.81–1.26)	0.953	1.000
rs7667298	5′ UTR	55686488	T to C	226 (44.7)	486 (47.2)	1.11 (0.89–1.37)	0.352	1.000
rs2239702	5′ UTR	55686896	G to A	121 (24.9)	263 (25.5)	1.03 (0.81–1.32)	0.789	1.000

A total of 515 patients with age-related macular degeneration (cases) and 253 ethnically-matched individuals without age-related macular degeneration (controls) were genotyped for twenty single nucleotide polymorphisms (SNPs) in the VEGFR-2 gene. The Location in gene column refers to the location of the SNP within the VEGFR-2 gene. The Genomic location column identifies the specific location of each SNP on Chromosome 4. The Variation column indicates the nature of the polymorphism from the normal allele to the variant allele. The frequency of the minor allele for each SNP was compared in cases and controls by the chi-square test. Odds ratios, 95% confidence intervals (CI), and p-values are reported. Adjusted p-values have been corrected for multiple comparisons using the Bonferroni method.