Molecular Vision: Fang, Mol Vis 2009; 15:2710-2719. Table 1

Table 1. Allele distribution for single nucleotide polymorphisms in VEGFA

SNP	Location in gene	Genomic location	Variation	Variant allele in controls, n (%)	Variant allele in cases, n (%)	Odds ratio (95% CI)	Unadjusted p-value	Adjusted p-value
rs699947	5′ UTR	43844367	A to C	267 (52.8)	500 (48.5)	0.84 (0.68–1.05)	0.120	1.000
rs25648	Exon 1	43846955	C to T	98 (19.4)	188 (18.3)	0.93 (0.71–1.22)	0.598	1.000
rs1413711	Intron 1	43848656	G to A	240 (47.4)	528 (51.3)	1.17 (0.94–1.44)	0.158	1.000
rs833068	Intron 2	43850505	G to A	153 (30.2)	342 (33.2)	1.15 (0.91–1.44)	0.242	1.000
rs2146323	Intron 2	43853073	C to A	189 (37.4)	362 (35.1)	0.91 (0.73–1.13)	0.376	1.000
rs3025030	Intron 7	43858565	G to C	67 (13.2)	137 (13.3)	1.01 (0.73–1.38)	0.974	1.000
rs3025035	Intron 7	43859337	C to T	34 (6.7)	77 (7.5)	1.12 (0.74–1.70)	0.591	1.000
rs3025039	3′ UTR	43860514	C to T	66 (13.0)	137 (13.3)	1.02 (0.75–1.40)	0.889	1.000
rs10434	3′ UTR	43861190	G to A	246 (48.6)	484 (47.0)	0.94 (0.76–1.16)	0.549	1.000

A total of 515 patients with age-related macular degeneration (cases) and 253 ethnically-matched individuals without age-related macular degeneration (controls) were genotyped for nine single nucleotide polymorphisms (SNPs) in the VEGFA gene. The Location in gene column refers to the location of the SNP within the VEGFA gene. The Genomic location column identifies the specific location of each SNP on Chromosome 6. The Variation column indicates the nature of the polymorphism from the normal allele to the variant allele. The frequency of the minor allele for each SNP was compared in cases and controls by the chi-square test. Odds ratios, 95% confidence intervals (CI), and p-values are reported. Adjusted p-values have been corrected for multiple comparisons using the Bonferroni method.