Figure 2. Genes known to be regulated by SP1 that showed significant differences in expression after transfection with miR-29b mimic by array analysis. Metacore analysis of the genes showing significant differences (p<0.5) in expression in the Affymetrix U133A2 arrays identified SP1 as the transcription factor more significantly (p= 4.82 E-106) associated with these gene expression changes. Green lines represent upregulation by SP1, red lines a downregulation, and gray lines an unspecified effect. Genes significantly upregulated in gene array analysis of cells transfected with miR-29b are labeled with red dots. Genes significantly downregulated by miR-29b are labeled with blue dots. Inconsistencies between the array data and the effects predicted by Metacore based on the literature are labeled with a star.