Table 1 of Bassnett, Mol Vis 2009; 15:2448-2463. Table 1 of Bassnett, Mol Vis 2009; 15:2448-2463.
Table 1. Members of the solute carrier (Slc) family of transport proteins identified in the lens fiber cell membrane proteome.
| Gene symbol | Protein name (short name) |
Substrate |
|---|---|---|
| Slc1a4 | Neutral amino acid transporter A | Glutamate/neutral amino acids |
| Slc2a1 | Facilitated glucose transporter 2 (Glut-1) | glucose |
| Slc3a2 | 4F2 cell-surface antigen heavy chain (CD98) Forms heterodimeric transporter with Lat1 or Lat2 | Neutral amino acids (phenylalanine, tyrosine, leucine, and tryptophan) |
| Slc6a6 | Sodium- and choloride-dependent taurine and beta-alanine transporters | Taurine, beta alanine |
| Slc7a1 | High affinity cationic amino acid transporter 1 (Cat1) | Arginine, lysine and ornithine |
| Slc7a4 | Cationic amino acid transporter 4 (Cat4) | Arginine, lysine and ornithine |
| Slc7a5 | Large neutral amino acids transporter small subunit 1 (Lat1) | phenylalanine, tyrosine, leucine, arginine and tryptophan. |
| Slc7a6 | Y+L amino acid transporter 2 (y+Lat2) | When co-expressed with Slc3a2 mediates the uptake of arginine, leucine and glutamine. Acts as an arginine/glutamine exchanger. Involved in sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of neutral amino acids. |
| Slc8a1 | Sodium/calcium exchanger 1 (NCX1) | Sodium, calcium |
| Slc12a2 | Bumetanide-sensitive sodium – (potassium) chloride co-transporter 1 (Nkcc1) | Sodium, potassium, chloride |
| Slc15a1 | Peptide transporter 1 (Pept1) | H+, oligopeptides |
| Slc20a2 | Sodium-dependent phosphate transporter 2 (PiT-2) | phosphate |
| Slc24a4 | Sodium/potassium/calcium exchanger 4 (Nckx4) | Sodium, potassium, calcium |
| Slc31a1 | High affinity copper uptake protein 1 (Ctr1) | copper |
| Slc35f1 | Solute carrier family 35 member F1 | Putative nucleoside-sugar transporter |
| *Slc25a3 | Phosphate transport protein (PTP) | phosphate |
| *Slc25a4 | ADP/ATP translocase 1 (ANT1) | ADP,ATP |
| *Slc25a5 | ADP/ATP translocase 2 (ANT2) | ADP, ATP |
| *Slc25a11 | 2-oxoglutarate/malate carrier protein (OGCP) | 2-oxoglutarate, malate |