Figure 1. MudPIT analysis of the lens
fiber cell membrane proteome. A: More than 200 membrane
proteins and membrane-associated proteins were identified. The ten
proteins of highest apparent abundance are indicated. For each protein,
the number shown in parentheses is the lens preferred expression index
(LPEI), a measure of the relative level of expression of the RNA for
that protein in the lens compared to a panel of 96 other tissues and
cell types (see text for details). The percentage value for each
protein relates to its representation on that particular pie chart. B:
Eighty-seven integral membrane proteins were detected. Six proteins
(including three connexin proteins; Gja3, Gja8, Gje1) account for
>75% of the integral plasma membrane proteins detected in MudPIT
analysis of lens fiber membranes.