Table 1 of Nicoli, Mol Vis 2009; 15:259-266. Table 1 of Nicoli, Mol Vis 2009; 15:259-266.
Table 1. Permeation parameters obtained for acetaminophen, FD-150, and insulin through human and porcine scleras from donor solutions at pH 7.4.
| Compound | Permeation parameters | Human sclera | Porcine sclera | p value |
|---|---|---|---|---|
| Acetaminophen | Flux (µg/cm2h) | 626±55 | 280±37 | <0.001 |
| P (cm/s) x10−6 | 34.9±3.0 | 15.6±2.1 | 0.00047 | |
| DK (cm2/s) x10−6 | 2.05±0.18 | 1.95±0.26 | 0.8043 | |
| Lag-time (min) | - | 35±2 | - | |
| FD-150 | Flux (µg/cm2h) | 1.72 0.23 | 0.57±0.03 | 0.0147 |
| P (cm/s) x10−6 | 0.48±0.067 | 0.16±0.072 | 0.0147 | |
| DK (cm2/s) x10−6 | 0.028±0.004 | 0.019±0.009 | 0.4885 | |
| Lag-time (min) | 28±7 | 57±7 | 0.0265 | |
| Insulin | Flux (µg/cm2h) | 6.93±1.14 | 3.74±2.10 | 0.1786 |
| P (cm/s) x10−6 | 1.93±0.32 | 0.85±0.48 | 0.1786 | |
| DK (cm2/s) x10−6 | 0.11±0.02 | 0.11±0.05 | 0.9321 | |
| Lag-time (min) | 71±6 | 198±23 | <0.001 |