Figure 3. Permeation profiles of
acetaminophen, FD-150, and insulin for porcine and human sclera.
Profiles for acetaminophen (A), FD-150 (B), and insulin (C)
through porcine (○) and human (●) sclera are shown. Open squares
(□) in panel A indicate the permeation profile of acetaminophen
through fresh porcine sclera. Transscleral fluxes obtained for all
three molecules tested were higher for human sclera. In particular, the
fluxes through human sclera were 2 times greater than through pig
sclera in the case of acetaminophen and insulin, and 3 times greater in
the case of FD-150. Permeability of acetaminophen through fresh porcine
sclera confirmed that the freezing procedure did not have any effect on
tissue permeability. Mean value ±SEM
