Figure 8. Fine mapping of the cord1 critical region. Twenty-four polymorphic markers on CFA15 were studied for the association with PRA in MLHDs. In total, 74 PRA cases and 86 controls were used for this fine mapping across the originally reported region of homozygosity [19]. Note that for the marker with the highest value at 21.34 Mb (RPGRIP1 insertion, arrow) the p-value is below the minimum detectable in the simulation, that is <1x10⁻¹¹. The aqua-highlighted area corresponds to the 1.74 Mb region of homozygosity shared by all PRA cases having two copies of the RPGRIP1 insertion.