Figure 3. Pioglitazone inhibited the ability of corneal fibroblasts to contract free-floating collagen lattices. Corneal fibroblasts were seeded in collagen gel lattice in the absence or presence of pioglitazone at the concentrations of 3 and 10 μm. Cell contractility was assessed by measuring the reduction in the surface area of the floating collagen gel discs for the times shown (1–5 d). A: Photographs of one representative experiment. B: Graphic representation of the mean±SD of three experiments.