Table 3 of Micheal, Mol Vis 2009; 15:2268-2278. Table 3 of Micheal, Mol Vis 2009; 15:2268-2278.
Table 3. Combined genotype analysis of methyltetrahydrofolate reductase C677T polymorphism with primary open angle glaucoma and controls.
| Combined Subjects | ||||||
|---|---|---|---|---|---|---|
| C677T | A1298C | Controls (143) | POAG (173) | OR (95%CI) | p (χ2) | p (χ2) |
| CC | AA | 14 (10%) | 25 (14%) | 0.64 (0.32-1.28) | 0.32 (2.2) | 0.83 (2.8) |
| CC | AC | 66 (46%) | 79 (46%) | 1.02 (0.65-1.59) | ||
| CC | CC | 21 (15%) | 19 (11%) | 1.39 (0.72-2.69) | ||
| CT | AA | 6 (4%) | 10 (6%) | 0.71 (0.26-1.94) | 0.76 (0.54) | |
| CT | AC | 30 (21%) | 34 (20%) | 1.08 (0.63-1.87) | ||
| CT | CC | 5 (3%) | 5 (3%) | 1.22 (0.37-4.01) | ||
| TT | AA | 0 (0%) | 0 (0%) | -------- | 0.51 (1.3) | |
| TT | AC | 1 (1%) | 1 (1%) | 1.21 (0.12-11.70) | ||
| TT | CC | 0 (0%) | 0 (0%) | ------- | ||
| Subjects of Pathan Ethnicity | ||||||
| C677T | A1298C | Controls (70) | POAG (96) | OR (95%CI) | p (χ2) | p (χ2) |
| CC | AA | 11 (16%) | 21 (22%) | 0.67 (0.30-1.47) | 0.09 (4.6) | 0.31 (7.1) |
| CC | AC | 33 (47%) | 45 (47%) | 1.01 (0.55-1.87) | ||
| CC | CC | 9 (13%) | 4 (4%) | 3.39 (1.05-10.85) | ||
| CT | AA | 6 (9%) | 8 (8%) | 1.03 (0.36-2.99) | 0.68 (0.76) | |
| CT | AC | 10 (14%) | 17 (18%) | 0.77 (0.34-1.79) | ||
| CT | CC | 0 | 1 (1%) | 0.00 (0.00-5.29) | ||
| TT | AA | 0 | 0 | -------- | N/A | |
| TT | AC | 1(1%) | 0 | -------- | ||
| TT | CC | 0 | 0 | -------- | ||
| Subjects of Punjabi Ethnicity | ||||||
| C677T | A1298C | Controls (73) | POAG (77) | OR (95%CI) | p (χ2) | p (χ2) |
| CC | AA | 3 (4%) | 4 (5%) | 0.78 (0.19-3.25) | 0.88 (0.24) | 0.71 (3.7) |
| CC | AC | 33 (45%) | 34 (44%) | 1.04 (0.55-1.98) | ||
| CC | CC | 12 (17%) | 15 (20%) | 0.81 (0.36-1.85) | ||
| CT | AA | 0 | 2 (3%) | 0.00 (0.00-2.02) | 0.32 (2.2) | |
| CT | AC | 20 (27%) | 17 (22%) | 1.33 (0.64-2.79) | ||
| CT | CC | 5 (7%) | 4 (5%) | 1.34 (0.37-4.82) | ||
| TT | AA | 0 | 0 | N/A | ||
| TT | AC | 0 | 1 (1%) | |||
| TT | CC | 0 | 0 | |||