Table 1 of Lam, Mol Vis 2009; 15:2217-2229. Table 1 of Lam, Mol Vis 2009; 15:2217-2229.
Table 1. Animal table: optic nerve transection and ocular hypertension.
| Optic Nerve Transection | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Duration |
Immunoreactivity in treated eye band |
||||||||||
| of | Treated | Hemisphere | GFAP | Mac-1 | |||||||
| ID# | Species | treatment
|
eye | processed | LGN | V1 | LGN | V1 | |||
| ONT 1 (AP75) | Rhesus | 14 days | R | R | NS | ++ | NS | NS | |||
| ONT 2 (32676) | Rhesus | 14 days | R | L | + | ++ | + | ++ | |||
| ONT 3 (AR 96) | Rhesus | 28 days | R | L | ++ | ++ | NS | NS | |||
| ONT 4 (19069) | Rhesus | 28 days | R | L | ++ | NS | NS | NS | |||
| ONT 5 (AP39) | Rhesus | 28 days | L | R | NS | + | NS | ++ | |||
| ONT 6 (Rh168) | Rhesus | 28 days | R | L | ++ | ++ | + | + | |||
| Ocular Hypertension (>30 mmHg) | |||||||||||
Tx eye mean |
Tx eye |
Immunoreactivity in treated eye band |
|||||||||
| IOP
mmHg |
cup/disk
|
Treated | Hemisphere | GFAP | Mac-1 | ||||||
| ID# |
Species | Duration | (C eye) | (C eye)
|
Integral
|
eye | processed
|
LGN | V1 | LGN | V1 |
| GL 1 (534) | Cynomolgus | 14 days | 48 (16) | 0.4 (0.4) | 672 | R | L | NS | + | NS | NS |
| GL 2 (452) | Cynomolgus | 40 days | 51 (16) | na (0.3) | 2040 | R | L | NS | ++ | NS | NS |
| GL 3 (AI 34) | Rhesus | 55 days | 46 (18) | 0.9 (0.2) | 2530 | R | R | ++ | ++ | - | - |
| GL 4 (529) | Cynomolgus | 56 days | 47 (14) | 0.9 (0.2) | 2632 | R | R | ++ | ++ | - | - |
| GL 5 (570) | Cynomolgus | 45 days | 40 (17) | 0.9 (0.3) | 1800 | R | R | NS | ++ | NS | NS |
| GL 6 (AS02) | Rhesus | 58 days | 35 (18) | 0.5 (0.3) | 2030 | L | L | ++ | ++ | - | - |