Figure 1. A schematic diagram of the human NR2E3 protein. A: Arrows indicate altered NR2E3 residues. Abbreviations: DNA binding domain (DBD), ligand binding domain (LBD), nuclear localization signal (NLS; NM_014249.2). B: NR2E3 protein sequence aligned to orthologs. By using ClustalW, we were able to align the sequence of human NR2E3 protein with those of chimp, rhesus, cow, mouse, opossum, chicken, frog, fugu, zebrafish, tetraodon, honeybee, mosquito, fruitfly, and roundworm. Amino acid residues conserved in all orthologs are indicated by asterisk, and lower identity or similarity is shown using either colon or a dot. Shadows indicate NR2E3 mutations analyzed in this report.