Table 3 of Radhakrishnan, Mol Vis 2009; 15:2146-2154. Table 3 of Radhakrishnan, Mol Vis 2009; 15:2146-2154.
Table 3. Represents the list of oncomirs in uveal melanoma, targeting tumor suppressor genes.
miRNA |
Chromosomal location |
Tumor suppressor genes |
Chromosomal location |
Tumor suppressor gene identified in other tumors and disorders |
|---|---|---|---|---|
| ▀miR-586 | 6p12.3 | CDKNIC | 11p15.5 | Cylin dependent kinase inhibitor 1c,Rhabdoid tumor [23] |
| ▀miR-493* | 14q32.1 | PDGFRL | 8p22-p21.3 | PDGF receptor beta-like tumor suppressor, Melanoma [24] |
| ▀miR-377 | 14q32.1 | CAV1 | 7q31.1 | Caveolin 1, caveolae protein, Lung carcinoma [25] |
| ▀miR-376c | 14q32.1 | CDKN1A | 6p21.2 | Cyclin dependent kinase inhibitor 1A, Laryngeal squamous cell carcinoma [26] |
| ▀miR-369-3p | 14q32.1 | FZD6 | 8q22.3-q23.1 | Frizzled homolog 6, melanocyte physiology, Uveal melanoma [13] |
| ▀miR-34c-5p | 11q23.1 | TGFBR2 | 3p22 | Tumor growth factor beta receptor 2, Colon cancer [27] |
| ▀miR-26a-2* | 12q14.1 | EXLT3 | 8p21 | Exotoses( multiple) like-3, Bone tumor [28] |
| ▀mir-218 | 4p15.31 | HYAL1 | 3p21.31 | Hyaluronoglucosaminidase 1, Head and neck squamous cell carcinoma [29] |
| ▀mir-19b-1* | 13q31.3 | RB 1 | 13q14.2 | Retinoblastoma 1 [30] |
| ▀mir-181a* | 1q31.3 | BRCA2 | 13q12.3 | Breast cancer type2 susceptibility protein, Breast cancer [31] |
| ▀mir-154 | 14q32.31 | NEK1 | 4q33 | (Never in mitosis gene a)-related kinase 1 [32] |
| ▀miR-133a | 18q11.2 | DLEC1 | 3p22-p21.3 | Deleted in lung and esophagael cancer, Gastrointestinal cancer [33] |
| ▀miR-129* | 7q32.1 | TSSC1 | 2p25.3 | Tumor suppressing subtransferable candidate 1 [34] |
| ▀mir-10a | 17q21.32 | LATS1 | 6q25.1 | Larger tumor suppressor, homolog1 [35] |
| ▀mir-1 | 1q13.33 | PINX1 | 8p23.1 | PIN2–interacting protein 1 [36] |
| ▀Let-7e | 19q13.33 | GAS1 | 9q21.3-q22 | Growth arrest specific 1, Melanoma [37] |
| ●mir-885-5p | 3p25.3 | PDGFRL | 8p22-p21.3 | Platelet–derived growth factor beta like tumor suppressor [24] |
| ●miR-585 | 5q35.1 | RPS29 | 14q22.1 | Ribosomal protein S29, colorectal cancer [38] |
| ●mir-640 | 19p13.41 | S100A2 | 2q14.3 | S100 calcium binding protein A2, Head and neck cancer [39] |
| ●miR-512-5p | 19q13.41 | BIN-1 | 2q14.3 | Bridging integrator, prostate cancer [40] |
| ●mir-556-5p | 1q23.3 | TP53 | 17p13.1 | Tumor suppressor protein P53, Osteoscarcoma [41] |
| ●mir-135b* | 1q32.1 | HYAL1 | 3p21.3-p21.2 | Hyaluronoglucosaminidase 1, Head and neck squamous cell carcinoma [29] |
| ●mir-325 | Xq21.1 | PTPRG | 3p14.2 | Protein tyrosine phosphatase receptor type G, Nasopharyngeal carcinoma [42] |
| ●mir-99a* | 21q21.1 | SEMA3B | 3p21.31 | Sema domain(Ig)short basic domain secreted, Lung cancer [43] |
| ●miR33a | 22q13.2 | TSC2 | 16p13.3 | Tuberous sclerosis protein 2, Lymphangioleiomyomatosis [44] |