Figure 2. Chromosome in situ hybridization for aberrations in chromosome 8 (extra whole chromosome and chromosome 1 (1p36). A: Invasive melanoma, hybridized with chromosome 8 showing trisomy in few cells and two copies in most of the cells. B: Non-metastasising melanoma, hybridized with chromosome 8 showing two copies in most of the cells. C: Normal retina hybridized with chromosome 8 showing two copies in all the cells. D: Invasive melanoma, hybridized with chromosome 1p36 showing one copy in all the cells. E: Non-metastasizing melanoma, hybridized with chromosome 1p36 showing two copies in most of the cells. F: Normal retina hybridized with chromosome 1p36 showing two copies in all the cells.