Figure 1. Chromogenic in situ hybridization for chromosome 3 and 8q22. A: Invasive melanoma, hybridized with chromosome 3 showing single copy in all the cells. B: Non-metastasising melanoma, hybridized with chromosome 3 showing two copies in most of the cells. C: Normal retina hybridized with chromosome 3 showing two copies in all the cells. D: Invasive melanoma, hybridized with chromosome 8q22 showing two copies in most of the cells. E: Non-metastasising melanoma, hybridized with chromosome 8q22 showing two copies in most of the cells. F: Normal retina hybridized with chromosome 8q22 showing two copies in all the cells.