Values are expressed as medians (range of grades), “n” was the numbers of the animals in each group every week. Median representation: 0, clear; 1, clear nuclear with wide sutures; 2, slight dense nuclear with opacities radiating from sutures; 3, dense nuclear without clefts; 4, dense nuclear with clefts; 5, nuclear cataract with clefts; 6, nuclear cataract with dense radial opacities; 7, nuclear cataract with whole lens opacities. Statistical analyses were performed by using Wilcoxon Rank Sum Test. The asterisk indicates significantly different from Group B; p<0.05 and the sharp (hash mark) indicates significantly different from Group D; p<0.05. Row A was the normal control group, row B was the diabetic rats untreated group, row C was the diabetic rats treated with carnosine eye drops (1% only) group, row D was the diabetic rats treated with aspirin eye drops (0.05% only) group, and row E was the diabetic rats treated alternately with carnosine (1%) and aspirin (0.05%) eye drops group. Stage 0.5 indicates that about half of the lenses were at stage 0 while the remainder had progressed to stage 1. Stage 1.5 indicates that about half of the lenses were at stage 1 while the remainder had progressed to stage 2. The numbers in 0 wk column represent the data in the lenses before receiving an intraperitoneal injection.