Figure 9. The effects of PSP on AKT and ERK1/2 signaling. The protein expression of phosphorylation and total AKT and ERK1/2 were assessed using total cellular protein lysates. PSP significantly reduced the level of phosphorylation of both AKT and ERK1/2 in HUVECs, although it had no effect on the total amount of AKT or ERK1/2 protein.