**Figure 1. **Meta-analysis of the V16A
variant for its association with neovascular AMD. Odds ratios (ORs,
black squares) and 95% confidence intervals (CIs, bars) are presented
for each study. Also shown is the shaded diamond of the summary OR
using the random-effects model of DerSimonian and Laird [

52]. The genotype data
included in the meta-analysis refer to the description of Kimura et al.
[

33] and Gotoh et
al. [

35].
Heterogeneity between studies was tested using Cochran’s Q statistic [

53,

54] and the

*I*^{2}
statistic for inconsistency [

53,

54]. Abbreviations:
AMD represents age-related macular degeneration.