Figure 2. Predicted membrane topology of
CLRN1. Disease-associated mutations are marked; the frameshift and
nonsense mutations are marked with red amino acids, missense mutations
are marked with blue amino acids, and the deleted amino acids replaced
by an insertion are marked with green. Transmembrane regions (1–4) were
predicted using a TMHMM2.0 program [
36].
The mutations studied in this article are
marked with red.