Table 2 of Park, Mol Vis 2009; 15:200-207. Table 2 of Park, Mol Vis 2009; 15:200-207.
Table 2. Distribution of genotypes for the seven tag-SNPs across SERPING1 and their association with AMD in the Mayo subjects
SNP |
Function |
Location |
Minor allele frequency |
Hardy–Weinberg equilibrium (p-value) |
Genotype |
Number AMD Cases (%) |
Number controls (%) |
Fisher p-value |
Log-additive p-value |
|---|---|---|---|---|---|---|---|---|---|
| rs2509897 | 2.4 K upstream | 57119193 | 0.36 | 0.87 | GG | 197 (42) | 122 (39) | 0.66 | 0.52 |
| GC | 204 (44) | 146 (47) | |||||||
| CC | 64 (14) | 42 (14) | |||||||
| rs2511990 | 2.3 K upstream | 57119284 | 0.5 | 0.19 | TT | 126 (27) | 80 (26) | 0.72 | 0.51 |
| TC | 223 (48) | 141 (46) | |||||||
| CC | 116 (25) | 84 (28) | |||||||
| rs3758919 | 2.2 K upstream | 57119379 | 0.11 | 0.92 | CC | 382 (81) | 236 (77) | 0.24 | 0.13 |
| CT | 80 (17) | 67 (22) | |||||||
| TT | 7 (1) | 5 (2) | |||||||
| rs1005511 | Intron 2 | 57123232 | 0.33 | 0.26 | GG | 208 (46) | 124 (43) | 0.43 | 0.7 |
| GA | 194 (43) | 137 (47) | |||||||
| AA | 52 (11) | 28 (10) | |||||||
| rs2508443 | Intron 6 | 57134568 | 0.4 | 0.37 | GG | 180 (38) | 104 (34) | 0.27 | 0.47 |
| GT | 211 (45) | 157 (51) | |||||||
| TT | 78 (17) | 48 (16) | |||||||
| rs2511989 | Intron 6 | 57134901 | 0.4 | 0.27 | GG | 179 (38) | 103 (33) | 0.27 | 0.44 |
| GA | 211 (45) | 157 (51) | |||||||
| AA | 80 (17) | 50 (16) | |||||||
| rs4926 | V480M (Exon 8) | 57138565 | 0.27 | 0.52 | GG | 252 (54) | 167 (54) | 0.14 | 0.36 |
| GA | 172 (37) | 124 (40) | |||||||
| AA | 47 (10) | 19 (6) |