Figure 5. Histological changes in retinal explants. A: The morphology of retinal explant at baseline (p9) is shown. B: In untreated retinas from rd1 mice (P16), ONL thickness was remarkably decreased. C: ONLs were preserved in retinas (P16) transfected for ASK-1 siRNA-2. D: The thickness of ONLs in untreated retinas of rd1 mice decreased with time while the ONLs from retinas transfected for siRNA-2 were significantly preserved. Filled circles indicate control rd1 mouse retina, and open circles represent rd1 mouse retina transfected for siRNA-2. Data are presented as the average±SD of three independent experiments. Asterisk (*) indicates p<0.05, and double asterisk (**) represents p<0.005 compared with control.