Table 3 of Geisert, Mol Vis 2009; 15:1730-1763.

Table 3. Seven new candidate genes for mapped, but uncloned human disease loci

New
candidate
gene

Disease

Human locus		 Mouse
locus
Chr @ Mb
Mapping
reference
Gnb1 Severe retinitis pigmentosa AR RP32 1p34.3-p13.3 4 @ 154.13 [81]
Adipor1 Retinitis pigmentosa AR AXPC1 1q31-q32 1 @ 134.28 [82]
Wdr17 Retinitis pigmentosa AR RP29 4q32-q34 8 @ 56.186 [58]
Egflam Macular dystrophy AD MCDR3 5p15.33-p13.1 15 @ 6.994 [83]
LOC77938 Age-related macular degeneration ARMS2 10q26.13 7 @ 132.59 [84]
MGC31549 Retinitis pigmentosa AR RP22 16p12.3-p12.1 7 @ 125.65 [85]
2810049P21Rik Central areolar choroidal dystrophy AD CACD 17p13 11 @ 68.79 [86]

When we examined the top 100 genes that correlate with the expression of Rhodopsin, 7 transcripts were identified that mapped to loci associated with human retinal diseases. For all 7 of these diseases the loci responsible for the disease were mapped but the genes were not identified (see selected loci on the RetNet Database, see Below). The 7 mouse genes and the diseases associated with the human loci are listed in this table.

Geisert, Mol Vis 2009; 15:1730-1763. http://www.molvis.org/molvis/v15/a185

©2009 Molecular Vision http://www.molvis.org/molvis/

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