Figure 3. IVCM images of rabbit CALT after
instillations with different PG eye drops. IVCM images of rabbit CALT
at H4 after BAC+latanoprost (A), BAC+travoprost
(B), BAC+bimatoprost (C), PBS (D), or
LCEm (E) instillations. Numerous inflammatory cells were
observed infiltrating the periphery and center of the CALT structure,
especially after the instillation of BAC+latanoprost. LCEm
did not induce any obvious inflammatory cell infiltration, as in the
PBS-instilled eyes. The scale bar indicates 100 μm. New IVCM scale
including CALT description shows the following toxicity order (F):
BAC+latanoprost > BAC+travoprost > BAC+bimatoprost
at H4. There was no significant difference between the PBS and LCEm
groups at all times. The asterisk indicates a p<0.0001 compared with
BAC+latanoprost. The double asterisk indicates a p<0.003
compared with BAC+latanoprost and the sharp indicates a
p<0.0002 compared with BAC+travoprost.