Figure 2 of Liang, Mol Vis 2009; 15:1690-1699.


Figure 2. IVCM images of rabbit ocular surface (cornea, limbus, and conjunctiva). IVCM images of rabbit ocular surface at H4 after BAC+latanoprost (A), BAC+travoprost (B), BAC+bimatoprost (C), PBS (D), and LCEm (E) instillations, of the superficial epithelium (line 1), the basal epithelium (line 2: 10–15 μm from the superficial epithelium layer), the limbus (line 3: about 20–30 μm from the superficial epithelium layer), and the conjunctival substantia propria (line 4: 50–80 μm from the superficial epithelium layer). BAC+Latanoprost and BAC+travoprost-treated eyes showed the greatest damage in the epithelium and the greatest inflammatory cell infiltration in the basal epithelium and limbus. BAC+Bimatoprost induced slight inflammation in the basal epithelium. These three BAC-containing eye drops induced inflammatory cells rolling in conjunctival blood vessels. PBS and LECm did not induce any obvious ocular surface microstructure damage. The scale bar indicates 100 μm. IVCM scores (F) for the five tested groups. BAC+Latanoprost and BAC+travoprost presented the highest IVCM toxic score at H4 and D1, with intermediate results for BAC+bimatoprost. The toxicity of LECm was less than that of the three BAC-containing commercial prostaglandins with no significant difference with the PBS group at all time points. The asterisk indicates a p<0.002 compared with BAC+latanoprost. The sharp indicates a p<0.002 compared with BAC+travoprost and the filled diamond indicates a p<0.05 compared with BAC+bimatoprost.