Figure 1. Microphotographs of typical clinical features after 15 instillations of different prostaglandins and Draize test evaluation at 4 h. Microphotographs of typical clinical features of instilled rabbit eyes at H4 for ^BAC+latanoprost- (A), ^BAC+travoprost- (B), ^BAC+bimatoprost- (C), PBS- (D), and latanoprost in cationic emulsion (LCEm)-treated groups (E). ^BAC+Latanoprost and ^BAC+travoprost induced diffuse hyperemia, chemosis, and purulent secretions on the ocular surface. ^BAC+Bimatoprost also induced mild conjunctiva hyperemia. LCEm-receiving eyes only presented slight hyperemia. Bar chart of ocular irritation evaluations using a modified Draize test scale (F) at H4 and D1. The asterisk indicates a p<0.0001 compared with the ^BAC+latanoprost-instilled group. The double asterisk indicates a p<0.01 compared with the ^BAC+latanoprost-instilled group, and the sharp (hash mark) indicates a p<0.001 compared with the ^BAC+travoprost-instilled group.