Figure 5. Effect of HP on the expression of adenylate cyclase mRNA in human ONH astrocytes. A: ADCY3 is upregulated in AA (black bars) compared to CA (white bars) astrocytes in the absence of HP (p<0.05, asterisks). Treatment with HP for 6 h also induces differential expression in AA compared to CA astrocytes (p<0.05, asterisk). B: Similar to ADCY3, ADCY9 is upregulated in AA (blue bars) compared to CA (white bars) astrocytes in the absence of HP (p<0.05, asterisk). Treatment with HP for 6 h also induces differential expression in AA compared to CA astrocytes (p<0.05, asterisk). In these experiments n=8 for controls and n=3 for the HP-treated groups. Error bars indicate SEM.