Figure 1. Pedigree of a six-generation family with six affected members. Blood (3 ml) was drawn from certain members (III:2, III:7, IV:1, IV:2, IV:3, IV:4, IV:5, V:1, V:2, V:3, V:4, and V:5) of the family. Solid squares mean male patients, open circles mean normal females, solid circles mean female patients, open squares mean normal males, arrow means proband, lines through circles and squares indicate deceased.