Table 12 of Sullivan, Mol Vis 2009; 15:1553-1572.

Table 12. Similarities and differences between the numbers of genes regulated by testosterone, 17β-estradiol and progesterone in the lacrimal and meibomian glands of ovariectomized mice.


Sex steroid effect on gene expression		 Lacrimal
gland		 Meibomian
gland
Testosterone ↑ 725 693
Testosterone ↓ 1304 273

17β-Estradiol ↑ 175 82
17β -Estradiol ↓ 188 87

Progesterone ↑ 93 25
Progesterone ↓ 137 134

17β -Estradiol + Progesterone ↑ 144 101
17β -Estradiol + Progesterone ↓ 198 188

17β -Estradiol ↑, Testosterone ↑ 13 12
17β -Estradiol ↓, Testosterone ↓ 17 5
17β -Estradiol ↑, Testosterone ↓ 24 1
17β -Estradiol ↓, Testosterone ↑ 42 13



Progesterone ↑, Testosterone ↑ 9 0
Progesterone ↓, Testosterone ↓ 13 11
Progesterone ↑, Testosterone ↓ 2 0
Progesterone ↓, Testosterone ↑ 19 12

17β -Estradiol + Progesterone ↑, Testosterone ↑ 17 12
17β -Estradiol + Progesterone ↓, Testosterone ↓ 29 11
17β -Estradiol + Progesterone ↑, Testosterone ↓ 30 4
17β -Estradiol + Progesterone ↓, Testosterone ↑ 46 23

The number of genes significantly (p <0.05) up (↑)- or down (↓)-regulated by steroid treatment of castrated mice is shown in the columns entitled “Lacrimal gland” and “Meibomian gland.” Results were obtained by comparing log-transformed data. The 17β-estradiol and progesterone data originated from other studies [42,43], for which the Association for Research in Vision and Ophthalmology is the copyright holder.

Sullivan, Mol Vis 2009; 15:1553-1572. http://www.molvis.org/molvis/v15/a166

©2009 Molecular Vision http://www.molvis.org/molvis/

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