Molecular Vision: El-Gayar, Mol Vis 2009; 15:1325-1331. Table 1

Table 1. Clinical details in study patients with primary congenital glaucoma I.

Proband	Age of onset	Age at Dx	Current age	Corneal Diameter V,H [mm]	Corneal Haze OD/OS	IOP [mmHg] OD/OS at Dx	IOP [mmHg] OD/OS Current	cIOP [mmHg] OD/OS	Gonioscopy OD/OS [Shaffer] or AC depth	Axial Length [mm] OD/OS	Refraction [SphericEquivalent] OD/OS	Cup-Disc Ratio OD/OS	Visual Acuity [Decimal] OD/OS	Treatment
Family 1
proband	at birth	at birth	10 y	12,12/12,12	mild/ mild	ND	19/23	18/22	1–2/1–2	22.74/ 25.17	−1.5/-9.75	0.4/0.8	1.0/0.2	OU Trab (7d); LE ALT+Trab (3y); OU Medications
Family 2
proband	at birth	“late”	24 y	14,14/13,13	clear/ clear	ND	45/45	46/43	3.5 h open, PAS/open	25.23/ 24.04	−3.75/.4.25	1.0/0.9	HM/0.1	OS Medications OS
Affected sibling	at birth	7 y	13 y	11,12/12,15	clear/ severe	ND	18/ digitally soft	18	2/deep AC	ND/ ND	−1.37/NA	0.7/NA	0.1/NLP	OD Trab+MMC (7y); OS no Rx.; OD Medications
Affected sibling	at birth	5 y	11 y	13,15/ND	mild/NA	ND	21/NA	28	1/NA	22.53/ NA	+0.5/NA	0.8/ND	0.5/NA	OD Trab (5y); OS enucleation (9y); OD Medications
Family 3
proband	at birth	5 d	11 y	12.5,12.5 / 12,12	mild / clear	ND	21 /13	10/08	normal AC/normal AC	23.05/ 20.92	0.0/+0.5	0.3/0.4	0.05/0.5	OD Trab (2w) (´3); OS Trab (2w) (´2); OU Medications
Family 4
proband	unclear	unclear	23 y	12.5,12.5/11.5,12.0	clear/ clear	>50/>50	17/15	19/16	3/3	ND/ ND	−3.37/-2.87	0.8/0.9	0.3/0.6	OU Trab (6y); OU Medications
Affected sibling	at birth	at birth	3 y	12.5,13/12.5,12.5; at 14 m: 11,11.5/11,11.5	clear/ clear	>50/>50	12/18	7/14	ND/ND	21.09/ 20.34, at 14 m: 19.92/ 19.67	−1.75/-2.0	0.0/0.0	0.5/0.5	OU Trab+Trab (3y); No medications
Family 5
proband	at birth	at birth	3 y	11,12/ND; at birth: 10,10/12,12	clear / NA	38 / 36	22 / NA	18	normal AC/NA	19.7/ NA, at birth: 18.47/ 19.27	−5.75/NA	0.1/NA	sc 0.05/NLP	OD Trab + Trab (3w); OS Trab + lensectomy+anterior vitrectomy (3w); No medications
Family 6
proband	at birth	at birth	3 y	11.5/12		>30/30	30/25	39/18				0.4/0.5	0.05/0.15 (low coop.)	OU Trab; No medications
Affected sibling	at birth	at birth	6 m	11.5,11.0/10,10	clear / clear	ND			normal AC/normal AC	18.64/ 18.63	−0.62/-1.37	0.5/0.9	follows light/follows light	Medications only; Awaiting Sx
Family 7
proband	at birth	at birth	20 y	8,9/9,11	severe/severe, at birth: BE “white cornea”	ND	NA/NA		NA/NA	NA/NA	NA/NA	NA/NA	NLP/NLP	OU Trab (9d) (x1) (5y); No medications
Affected sibling	at birth	at birth	18 y	-,17/-,17	severe/severe, at birth: BE “white cornea”	ND	BE digitally hard		NA/NA	>30/ >30	NA/NA	NA/NA	LP/LP	OU Trab (3–4y); No medications
Affected sibling	at birth	at birth	8 y	-,14.5/-,14.5	severe/severe, at birth: BE “white cornea”	ND	BE digitally hard		deep AC/deep AC	≈27/ ≈25	NA/NA	NA/NA	LP/LP	OU Trab (3–4m); No medications
Family 8
proband	unclear	12 y	26 y	12.5,12.5/12,12	mild/clear	ND	45/16	39/18	deep AC/deep AC	27.88/ 25.57	−11.9/-1.68	NA/1.0	LP/HM	OS Trab (22y); No medications
Affected sibling	< 1 y	1 y	23 y	14,14/13.5,14.5	clear / mild	ND	26/21	17/15	normal AC/normal AC	29.10/ 22.36	≈-6.5/NA	0.9/NA	0.075/NLP	OS Trab (1year); No medications
Affected sibling	at birth	at birth	18 y	12.5,12.5/13,13	severe/severe	ND	digitally soft/ digitally hard		NA/NA	≈13/ ≈25	NA/NA	NA/NA	NLP/NLP	OU Trab (20d);
Family 9
proband	1 m	1 m	17 y	10,10/19,19	severe/severe	ND	BE digitally soft		NA/NA	≈21/ ≈29	NA/NA	NA/NA	NLP/NLP	OS Trab (x7); No medications

All data refer to time of last examination except where stated differently. ALT – argon laser trabeculoplasty, d: day(s), Curr.: current, Dx: diagnosis, cIOP: pachymetry corrected intraocular pressure, H: horizontal, HM: hand movements, IOP: intraocular pressure, LP: light perception, m: month(s), MMC: mitomicin C, NLP: no light perception, w: week(s), NA: not applicable, ND: no data available, OD: right eye, OS: left eye, OU: both eyes, PAS: peripheral anterior synechia, Rx: Treatment, Sx: surgery, Trab – Trabeculectomy, Trab+trab: Trabeculectomy + Trabeculotomy, V-vertical, y: year(s).