Figure 8. Growth dynamics of choroidal neovascularization membranes following subretinal injection. Line and bar graphs (A-D) display changes in the thickness of choroidal neovascularization (CNV) membranes at post inoculation (PI) day 3, 7, 10, 14, and 21. CNV formation was more pronounced in eyes following retinal pigment epithelium (RPE) cells and microbeads with maximal extension at PI day 7 (A,B). CNV lesions were thicker in 2-month-old C57BL/6 mice compared to age-matched Ccl-2-deficient and aged 12-month-old C57BL/6 mice (C,D). Bars represent the means (n=5 eyes/group) at each time point (PI day 3, 7, 10, 14, and 21); error bars represent standard deviation (SD). The asterisk indicates p<0.05.