Figure 10. Scanning and transmission electron microscopic images of choroidal neovascularization membranes. Choroidal neovascularization (CNV) membranes (A, arrow) were partially covered by remaining photoreceptor cells after removal of the retina. Occasional microbeads (B, arrowheads) and doughnut-shaped erythrocytes are present at the inner CNV surface (B, arrows). CNV membranes were composed of fibroblasts, pigmented retinal pigment epithelial (RPE) cells, and non-pigmented RPE cells; a well structured surface was missing (C, arrows). The RPE monolayer (C, arrowheads) and photoreceptor outer segments (asterisks) next to the CNV margin appeared normal. High magnification images of the CNV lesions revealed pigment-laden RPE cells with intracytoplasmatic microbeads (black asterisks), spindle-shaped fibroblast (arrowheads), endothelial cells (arrow), and erythrocytes (white asterisk) within small-sized blood vessels (D).