Figure 8. Diagram of signal transduction cascades investigated in this study. In hypoxia, VEGF and annexin A2 transcription was upregulated by hypoxia inducible factor. VEGF directly effect on the expression of annexin A2, or a combination of VEGF and VEGFR2 induced the expression of annexin A2 on the surface of the cell membrane. VEGF and VEGFR2 also may be promote Annexin A2 expression by PKC pathway. Annexin A2 further influenced neovascularization.