Figure 8. Antagonism of PAF-induced cytokine release in HCECs. Concentration-response studies were conducted with two PAF antagonists
(CV-3988 and PC-42481) against a fixed concentration of PAF (1 µM) in HCECs isolated from different donor eyes, and the concentrations
of IL-6, IL-8, and GM-CSF released into the culture medium were determined by specific ELISA assays. The levels of the cytokines
produced by buffer alone or by PAF itself are also shown. Data are shown as mean±SEM from three or more experiments. a=p<0.05;
b=p<0.01, and c=p<0.001, each p value relative to the control. The PAF antagonists by themselves did not influence cytokine
release.