Figure 8 of Sharif, Mol Vis 2009; 15:1153-1161.


Figure 8. Antagonism of PAF-induced cytokine release in HCECs. Concentration-response studies were conducted with two PAF antagonists (CV-3988 and PC-42481) against a fixed concentration of PAF (1 µM) in HCECs isolated from different donor eyes, and the concentrations of IL-6, IL-8, and GM-CSF released into the culture medium were determined by specific ELISA assays. The levels of the cytokines produced by buffer alone or by PAF itself are also shown. Data are shown as mean±SEM from three or more experiments. a=p<0.05; b=p<0.01, and c=p<0.001, each p value relative to the control. The PAF antagonists by themselves did not influence cytokine release.