Figure 7. BER activities in neuroretina protein extracts. Representative gels showing the cleavage of the double-stranded radiolabeled oligonucleotide substrate containing 8-oxoG: C (A) and an abasic site analog (B). Lane C corresponds to experiments omitting protein extract used as negative control. Lanes 1 to 4 correspond to enzymatic activities detected in protein extracts from the adult mouse neuroretina. (S) indicates the substrate DNA and (P) the cleaved product.