Figure 1. Linkage disequilibrium structure across the pigment epithelium-derived factor gene in Chinese and Japanese populations. Genotype data were retrieved from HapMap CHB (Han Chinese in Beijing, China; A) and JPT (Japanese in Tokyo, Japan; B) data sets, and linkage disequilibrium (LD) patterns were assessed using Haploview software [47]. Haplotype blocks were determined using the “four-gamete rule” option in this software. Each box provides estimated statistics of the coefficient of determination (r²), with darker shades representing stronger LD.