Figure 1. En face near-infrared reflectance and autofluorescence images of the LCA5 patients. A: Near-infrared (NIR) reflectance (REF) image of the left fundus of P1 is shown. Inset to the left is a schematic drawing of the retinal regions corresponding to low reflection (black), intermediate reflection (hatched), and high reflection and choroidal visibility (white). Inset to the right is a NIR reflectance view of the fundus of a 6 year-old child with normal vision. B: Near-infrared-autofluorescence (NIR-AF) image of the left fundus of P1 is shown. Black arrows indicate the boundaries of the midperipheral transitions to healthier retinal pigment epithelium; and gray arrow points to the parafoveal annular region of low intensity. Inset is a normal image. C: NIR reflectance image of the left fundus of P2 is shown. Inset is an enlarged view of the optic nerve head (ONH) region with ONH drusen. D: NIR-AF image of the left fundus of P2 is shown. Inset is an enlarged view of the ONH region. All images are shown contrast stretched for visibility of features.