Figure 7. Schematic representation of phospholipids with different ClogP values, membrane-sequestered IsoPG endoperoxides, and the hydrate of iso[4]LGE₂. Previous studies of phospholipid conformations in membranes showed that sn-2 acyl groups whose methyl esters have ClogP of less than 2 protrude into the aqueous phase whereas with ClogP greater than 5, they are buried in the lipid bilayer. IsoPG endoperoxides that are generated have been schematically shown (iso[4]PGH₂ and iso[4]LGE₂). They remain sequestered in membranes where they slowly rearrange to isoLGs that become hydrated and protrude into the aqueous phase (iso[4]LGE₂·H₂O) allowing them to react with pyridoxamine or proteins.