Figure 10. Possible mechanisms of the phenotypes of MUC5AC-DTA. In immunohistochemical stainings (100X), the expression of anit-phospho-p38MAPK was detected in conjunctival goblet cells and conjunctival epithelial cells of transgenic mice but not in control mice (A,B). Both transgenic mice and control mice expressed the similar patterns of anti-phospho-ERK (C,D) and AP2 (E,F). The compensatory overexpression of MUC4 in MUC5AC-DTA mice is possibly mediated through the expression of p38MAPK.